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Pts randomized to chemo who had pd and met.
Jacob food. The keynote 024 trial was designed by merck representatives and academic advisors. Eligible pts were randomized to pembro 200 mg q3w for up to 35 cycles 2 years or chemo. At data cutoff july 10 2017 median follow up was 252 months range 204 to 337 months.
Nct02142738 is an international randomized open label phase iii study of pembrolizumab monotherapy versus platinum based chemotherapy in patients with previously untreated advanced nonsmall cell lung cancer nsclc with programmed death ligand 1 pd l1 tumor proportion score tps of 50 or greater and without egfr mutation or alk. The keynote 024 trial studied patients with advanced nsclc and high pd l1 expression defined as 50 of tumor cells seen in about one quarter of advanced nsclc patients and no sensitizing egfr mutations or alk translocations. We report updated efficacy and safety from keynote 024 with 5 years follow up.
Keynote 024 included 305 randomly assigned patients pembrolizumab n 154. Treatment with pembrolizumab has led to a near doubling of the 5 year overall survival os rate relative to chemotherapy among previously untreated patients with pd l1 high metastatic non small cell lung cancer report the keynote 024 investigators. Keynote 024 showed that 319 of patients treated with keytruda were alive at five years.
All except one patient in the chemotherapy arm received study treatment fig 1. Survival outcomes in these patients with metastatic lung cancer did not seem possible to many oncologists including myself several years ago added reck who has been involved in the several analyses of the trials data over the years. This enriched patient population was based upon data from keynote 001.
Data were collected by investigators and associated site personnel analyzed by statisticians employed by merck.
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