Keynote 024 Trial, Investor Call

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Nct02142738 is an international randomized open label phase iii study of pembrolizumab monotherapy versus platinum based chemotherapy in patients with previously untreated advanced nonsmall cell lung cancer nsclc with programmed death ligand 1 pd l1 tumor proportion score tps of 50 or greater and without egfr mutation or alk. These data establish pembrolizumab as a new treatment option for this population and validate the use of pd l1 selection. Five year survival data from the phase 3 keynote 024 trial evaluating keytruda for the first line treatment of patients with advanced non small cell lung cancer nsclc whose tumors expressed pd l1 tumor proportion score 50 abstract lba51.
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This enriched patient population was based upon data from keynote 001.

Tatarstan kazan russia. Pembrolizumab prolongs overall survival and has a favourable benefit to risk profile in patients with previously treated pd l1 positive advanced non small cell lung cancer. The keynote 024 trial studied patients with advanced nsclc and high pd l1 expression defined as 50 of tumor cells seen in about one quarter of advanced nsclc patients and no sensitizing egfr mutations or alk translocations. Survival outcomes in these patients with metastatic lung cancer did not seem possible to many oncologists including myself several years ago added reck who has been involved in the several analyses of the trials data over the years.

Data were collected by investigators and associated site personnel analyzed by statisticians employed by merck. Keynote 024 showed that 319 of patients treated with keytruda were alive at five years. This is a study to assess the efficacy and safety of pembrolizumab mk 3475sch 900475 compared to standard of care soc platinum based chemotherapies in the treatment of participants with previously untreated stage iv programmed cell death ligand 1 pd l1 strong expressing non small cell lung cancer nsclc.

The keynote 024 trial was designed by merck representatives and academic advisors. N engl j med 20163751823 33. In the international open label phase iii keynote 024 trial nct02142738 adults with previously untreated advanced nsclc without egfr sensitizing mutations or alk translocation that expresses pd l1 in 50 of tumor cells are randomized 11 to receive a 200 mg fixed dose of pembrolizumab intravenously every 3 weeks or.

In the first line setting the open label randomized phase iii keynote 024 trial showed that pembrolizumab was more effective if compared with platinum based chemotherapy in nsclc patients with high levels of pd l1 expression tumor proportion score tps of 50 or higher.

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Keynote 024 Trial, Investor Call

This enriched patient population was based upon data from keynote 001.

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