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Pleural synovial sarcoma. Phenotypic analysis of b luciferase gfp nci h1975 cell line. Similarly h1975 was classified as a ercc1 low p53 gof cell line and pc14 was classified as a ercc1 high p53 gof cell line. This guide organizes our atcc tumor cell lines according to gene of in terest and provides information for each line about the specific mutation predicted protein sequence zygosity and tumor histology.
The tissue donor was a non smoker. 99100 based on 404 pubmed citations. For further information on this cell line and other parameters including different strains vendors implant type and location andor standards of care please contact covance.
We have collected this information together so that you can quickly select the cell lines that best suit your research needs. New approaches in lung cancer therapy are crucial in treating advanced stage patients. The information on the 8 cell lines is listed in abbreviated form based on ercc1 expression level and p53 status in supplementary table s1.
Zero bias scores article reviews protocol conditions and more. The cells are provided as service to the research community. Imaging under fluorescence microscopy showed green fluorescent expression of b luciferase gfp nci h1975 cell line.
Homo sapiens vulgar name. The nci h1975 cell line harbors not only the l858r mutation but also the t790m mutation. The line was established in july 1988.
Neither the cell line nor products derived from it may be sold or used for commercial purposes. The expression of luciferase was detected by bright glotm luciferase assay system promega cat e2610. Home industry solutions oncology preclinical cell lines nci h1975 human non small cell lung carcinoma.
Nci h1975 h 1975 h1975 species. H1975 non small cell lung cancer cells express a double mutated active erbb1 and for a patient with such a tumor afatinib would be the standard of care treatment. Non small cell lung cancer is frequently diagnosed at advanced stages with the average 5 year survival rate of only 16.
The present study used the nci h1975 cell line which is genetically different from the cell lines mentioned above. Nor can the cells be distributed to third parties for purposes of sale or producing for sale cells or their products. Nci h1975 h 1975 h1975.
In order to develop a gefitinib resistant cell line the nci h1975 cells were exposed to increasing concentrations of gefitinib.
Fgl1 Regulates Acquired Resistance To Gefitinib By Inhibiting Apoptosis In Non Small Cell Lung Cancer Research Square Pleural Synovial Sarcoma
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