Sv40 Mesothelioma Vaccine Pubmed, Summary Of Sv40 Analysis In Malignant Mesothelioma And Normal Kidney Download Table
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An unknown proportion of formalin inactivated poliovirus vaccine lots administered to millions of us residents between 1955 and 1963 was contaminated with small amounts of infectious simian virus 40 sv40 a polyomavirus of the rhesus macaque.
Sunshine coloring page. The results suggest that the sv40 like sequences detected in mesothelioma tissue in some previous studies may indeed originate from sv40 contaminated polio vaccines. Jasani b1 coleman s butchart e evans em adams m mason m gibbs a tabi z. It is a matter of speculation whether the absence of sv40 infection has contributed to the relatively low incidence of mesothelioma in finland 1105 in 1990 1995.
Hamsters injected intracardially to expose most tissue types to sv40 preferentially develop mesotheliomas. In humans asbestos is the main cause of mesothelioma and asbest. Simian virus 40 sv40 is a dna tumor virus capable of infecting and transforming human mesothelial hm cells in vitro.
Many of these reports linked sv40 to human mesotheliomas. Simian virus 40 sv40 has been detected in human tumors in over 40 different laboratories. The vaccine safety committee of the institute of medicine iom national academy of sciences usa recently reviewed the evidence associating polio vaccines andor sv40 with human tumors.
Simian virus 40 sv40 is a dna virus isolated in 1960 from contaminated polio vaccines that induces mesotheliomas lymphomas brain and bone tumors and sarcomas including osteosarcomas in hamsters.
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