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Reactive mesothelial cells vs mesothelioma. In situ hybridisation against p16 is a promising method of differentiating malignant mesothelioma from reactive mesothelium. Immunohistochemistry is used to distinguish sarcomatoid malignant mesotheliomas smm from spindle cell and pleomorphic carcinomas spc but there are no guidelines on how to interpret cases that show overlapping or equivocal immunohistochemical findings. Including immunohistochemistry and electron microscopy.
However most of these markers have been used for differentiating epithelioid mesothelioma from adenocarcinoma but not for characterizing sarcomatoid mesothelioma18 moreover the effectiveness of immunohis. A number of immunohistochemical markers have been pro posed in recent years. A systematic literature review of the immuno.
The definition of sarcomatoid carcinoma described in the who 2004 criteria is poorly differentiated nonsmall cell lung carcinomas that contain a component of sarcoma or sarcomalike spindle andor giant cells differentiation. See also the use of immunohistochemistry in effusion cytology. Hematoxylin and eosin stain showing malignant spindle cells x375 that are cytokeratin positive b upper right x375 and.
To determine the utility of immunohistochemistry in the differentiation of sarcomatoid malignant mesotheliomas from other spindle cell neoplasms the authors studied the immunostaining patterns of nine antibodies in four sarcomatoid mesotheliomas one desmoplastic mesothelioma two epithelial mesotheliomas four spindle cell squamous carcinomas and eight sarcomas of various differentiation. Fibrous pleurisy may show spaces mimicking fat fake fat surrounded by cytokeratin positive spindle cells a source of confusion with desmoplastic. Positive for cytokeratins including ck56 and calretinin references 1 padgett dm cathro hp wick mr et al.
Sarcomatoid malignant mesothelioma of the pleura.
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