Sarcomatoid Malignant Mesothelioma Keytruda, Research Says To Include Sarcomatoid Mesothelioma In Studies
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- Mesothelioma Versus Adenocarcinoma Immunohistochemistry
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The keynote 028 clinical trial conducted in 13 different sites across six different countries was the first to show success using keytruda to treat malignant pleural mesothelioma patients who were previously treated with chemotherapy or were considered ineligible for treatment.
Mesothelioma versus adenocarcinoma immunohistochemistry. Mesothelioma tumors include a protein called pd l1. Fda provides approval of keytruda for treatment of mesothelioma and other tumors published on june 18 2020 following confirmation of positive results the us. Malignant mesothelioma tumors often express high levels of pd l1 which is typically a requirement for keytruda eligibility.
Keytruda is an immune checkpoint inhibitor which in short means it props up the immune system. Food and drug administration has approved the use of the immunotherapy drug pembrolizumab keytruda for patients diagnosed with unresectable or metastatic malignant mesothelioma as. Interestingly keytruda performed better in mesothelioma patients with a low total proportional score for pd l1 expression in the promise meso trial although the numbers were small.
Malignant sarcomatoid mesothelioma is the least common and most aggressive histological type of malignant mesothelioma. In more technical terms keytruda stops cancerous proteins from subduing the immune system.
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