Role Of Sv40 In Mesothelioma, Frontiers New Perspectives On Diagnosis And Therapy Of Malignant Pleural Mesothelioma Oncology
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The possible role of the simian virus 40 sv40 mesothelioma applied research foundation one highly contentious issue is the role of simian virus 40 sv40 in the development of mesothelioma tumors.
Pumpkin ideas without carving. Evidence of a possible role of viruses in cancer first emerged in the early 1900s and was confirmed after the discovery of epstein barr virus ebv in burkitts lymphoma cells. Sv40 is a dna tumor virus thrust upon human populations primarily as a contaminant in various vaccine preparations. Some estimates suggest that millions of people are currently infected with the virus.
Found in rhesus monkeys this virus has been associated with the development of malignant mesothelioma cases. Laser microdissection experiments conducted in the laboratory of adi gazdar demonstrated that sv40 was present specifically in the malignant mesothelioma cells and not in nearby stromal cells. In humans asbestos is the main cause of mesothelioma and asbestos and sv40 are co carcinogens in transforming hm cells in tissue culture and in causing mesothelioma in hamsters.
Presence and role of simian virus 40 sv40 in malignant pleural mesothelioma. The virus causes primary brain tumors bone tumors lymphomas and mesotheliomas when injected into some rodent models.
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