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Cytologic Differential Diagnosis Among Reactive Mesothelial Cells Malignant Mesothelioma And Adenocarcinoma Kitazume 2000 Cancer Cytopathology Wiley Online Library Carson Lawrence
Carson lawrence. The pleural mesothelium differentiates to give rise to the endothelium and smooth muscle cells via epithelial to mesenchymal transition emt. Although mesothelial cells have a distinctive morphology reactive mesothelial cells may display atypical appearances that can be interpreted as malignancy. Metastatic adenocarcinoma is the most common malignancy diagnosed on effusions.
It can also be the result of trauma or the presence of metastatic tumor. Pleural mesothelial cells pmcs derived from the mesoderm play a key role during the development of the lung. Numerous mesothelial cells are seen in this pleural fluid from a dog with a transudative effusion with concurrent diapedesis of red blood cells or hemorrhage.
During development the mesoderm maintains a complex relationship with the developing endoderm giving rise to the mature lung. Reactive mesothelial cells can be found when there is an infection or an inflammatory response present in a body cavity. Mesothelial hyperplasia is often accompanied by pleural fibrosis figure 2324 in cases of subpleural inflammation and especially when inflammation is chronic active and may occur as micropapillary fronds of mature connective tissue covered by a single layer of flattened to cuboidal mesothelial cells figure 2325.
One of the characteristic cytomorphologic features of adenocarcinoma is the presence of intracytoplasmic. This condition can be caused by the presence of bacterial viral or fungal. This condition can be due to the presence of a bacterial viral or fungal infection.
The mesothelial cells have central round nuclei with a moderate amount of light purple cytoplasm and a corona or fringe to the cytoplasmic borders. It can also be the result of trauma or the presence of metastatic cancer.
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