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Pemetrexed Plus Carboplatin In Elderly Patients With Malignant Pleural Mesothelioma Combined Analysis Of Two Phase Ii Trials British Journal Of Cancer Mesothelioma Of Childhood
Mesothelioma of childhood. Mesothelioma of peritoneal origin has wider variation in treatment outcomes than mesothelioma of pleural origin likely because peritoneal mesothelioma comprises borderline malignant variants and aggressive malignant peritoneal mesothelioma mpem. Pemetrexed has proven effective in the treatment of malignant mesothelioma alone or in combination. Primary malignant peritoneal mesothelioma is a rare malignancy with an unfavorable prognosis.
Lana bijelic 1 o. Our patient responded well not only to initial treatment but also on rechallenging the cisplatin and pemetrexed on progression of his peritoneal malignant mesothelioma. He was switched to intravenous pemetrexed and cisplatin for one cycle then had a new.
On average peritoneal mesothelioma patients survive six months to one year. This strategy may be an option for some patients who show response initially. Anthony stuart 2 and paul sugarbaker 1 author information article notes.
Adjuvant bidirectional chemotherapy with intraperitoneal pemetrexed combined with intravenous cisplatin for diffuse malignant peritoneal mesothelioma. Because pm differs considerably from plm in clinical features the efficacy and safety of these therapies have yet to be established. Pemetrexed and platinum have been used for advanced pm following malignant pleural mesothelioma plm.
This study retrospectively evaluates the efficacy of first line systemic pemetrexed and cisplatin chemotherapy in mpem. Mesothelioma is a malignant tumor derived from mesothelial cells of the pleura peritoneum and pericardium.
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