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Nintedanib In Combination With Pemetrexed And Cisplatin For Chemotherapy Naive Patients With Advanced Malignant Pleural Mesothelioma Lume Meso A Double Blind Randomised Placebo Controlled Phase 3 Trial The Lancet Respiratory Medicine Prognosis Of Pleural Mesothelioma
Prognosis of pleural mesothelioma. Because mesothelioma is such a rare cancer its tough to do a study. Nearly 3 000 americans are diagnosed with mesothelioma each year and approximately the same number will die from the disease annually. Maintenance chemotherapy with pemetrexed is not the standard treatment of choice in patients with locally advanced or metastatic epiteliomorfe malignant pleural mesothelioma empm.
Patients in the upcoming trial will receive durvalumab with chemotherapy every three weeks for up to six cycles followed by maintenance with durvalumab every four weeks. The most common mesothelioma chemotherapy drugs are pemetrexed alimta cisplatin and carboplatin. Chemotherapy is a standard treatment for mesothelioma.
In the absence of routine maintenance treatment in mesothelioma randomisation to a study drug versus placebo is appropriate whilst a single arm study would be difficult if not impossible to interpret. If there is. It warrants confirmation in a randomized phase iii trial.
The combination of pemetrexed and a platinum based chemotherapy drug is the only fda approved chemotherapy for mesothelioma. One benefit of maintenance chemotherapy for mesothelioma even if we dont know for sure the benefit is that a patient is being seen by a doctor on a regular basis. Peter odwyer chief executive officer at precog llc.
We would assess the safety and efficacy of a treatment with pemetrexed until progression disease after 4 or 6 cycles of induction therapy with or without platin. For mesothelioma maintenance therapy often involves administering drugs after surgery or chemotherapy. Now researchers in japan report that the chemotherapy drug alimta when used as maintenance therapy could be the next standard of treatment.
Your doctor may use the same chemotherapy drugs or new drugs at this stage. Phase iii clinical trials have proven that the addition of alimta extends survival times. In search of a maintenance therapy for mesothelioma malignant pleural mesothelioma is an aggressive cancer that is very hard to treat.
This is a remarkable result in mesothelioma said dr. Platinum based chemotherapy drugs like cisplatin have been especially important for intraoperative procedures in mesothelioma patients. There are just a small number of patients when compared with other cancers.
Pdf Long Progression Free Survival By Pemetrexed Continuation Maintenance Therapy Following Cisplatin Based Chemotherapy In Malignant Pleural Mesothelioma Prognosis Of Pleural Mesothelioma
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