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Lymphohistiocytoid mesothelioma lhm is a term proposed to designate a variant of mesothelioma that assumes a histiocytoid morphology and contains intense lymphocytic infiltrates.
Color activities for preschool printable. Lymphohistiocytoid mesothelioma lhm is a term proposed to designate a variant of mesothelioma that assumes a histiocytoid morphology and contains intense lymphocytic infiltrates. The lymphohistiocytoid variant of diffuse malignant mesothelioma is rare with very few cases described in the literature. It is characterized by mesothelial cells with a histiocytelike appearance and an associated dense lymphoid infiltrate.
For lymphohistiocytoid mesothelioma cells most often resemble those seen in lymphoma the cancer of the lymphocytes of the lymphatic and immune systems. A rare lymphomatoid variant of predominantly sarcomatoid mesothelioma. Tumors are made up of a dense bundle of inflammatory immune cells including lymphocytes a type of white blood cell plasma cells and immobile immune cells called histiocytes.
According to a study published in the american journal of clinical pathology lymphohistiocytoid mesothelioma is a variant of sarcomatoid mesothelioma. Lymphohistiocytoid mesothelioma is a rare subtype of asbestos cancer that makes up less than 1 percent of all asbestos related cancer cases. Reports on this variant are few and its clinicopathologic and ultrastructural characteristics are still to be defined.
In lymphohistiocytoid mesothelioma as in the usual examples of sarcomatoid mesothelioma the demonstration of cytokeratin expression by the neoplastic cells is the most useful diagnostic finding that allows exclusion of other neoplasms with which this entity may be confused. Lymphohistiocytoid mesothelioma lhm reported to be a rare variant of sarcomatoid mesothelioma is challenging to differentiate from non hodgkins lymphoma due to marked lymphocytic infiltration. We studied clinicopathologic features and immunohistochemic.
1department of pathology flinders medical centre bedford park south australia. Mesothelioma is a rare cancer of the respiratory system and lymphohistiocytoid mesothelioma is far rarer making up less than 1 percent of all cases. This is a rare subtype constituting less than 1 of all of malignant mesotheliomas 3it has traditionally been classified with sarcomatoid mesothelioma but its prognosis is more in keeping with the usual epithelioid mesothelioma.
In the few reported cases of lymphohistiocytoid mesothelioma most patients were first told they had lymphoma.
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