Large Cell Neuroendocrine Carcinoma Lung Cytology, Classification Of Pulmonary Neuroendocrine Tumors New Insights Pelosi Translational Lung Cancer Research

217255256 histologically cell nesting with peripheral palisading of nuclei large cells with prominent nucleoli a high mitotic rate 1010 high.

Central lung cancer. Large cell neuroendocrine carcinoma lcnec has emerged as a separate entity among pulmonary endocrine neoplasms and the criteria for its histologic diagnosis are now well described. Pulmonary carcinoma with rhabdoid cells is a rare tumor with a dismal prognosiswe report a case of large cell neuroendocrine carcinoma with frequent rhabdoid cells found in imprint cytology. Large cell carcinoma by definition large cell undifferentiated carcinoma lacks the microscopic features of the other lung carcinomas therefore this diagnosis is made by exclusion.

Should be distinguished from atypical carcinoid basaloid squamous cell carcinoma and adenocarcinoma although diagnosis can be difficult on small biopsies or cytology specimens. The classification of pulmonary neuroendocrine neoplasms is par ticularly controversial. A 37 year old man reporting right chest and back pain and bloody sputum was found in chest computed tomography ct to have a well demarcated mass 14 cm in diameter in the upper right.

It accounts for about 10 of all lung cancers and it is most commonly located peripherally. 217 this entity is a non small cell carcinoma without squamous or glandular differentiation with morphological features suggesting neuroendocrine differentiation which can be confirmed by immunocytochemistry or em. A 64 year old woman presented with axillary and cervical lymph nodes swelling.

Large cell neuroendocrine carcinoma is included as a subtype within the large cell carcinoma category in the who classification. The tumor is classified as a non small cell lung carcinoma and is diagnosed based on the examination of a tumor sample by a pathologist under a microscope. Due to the rarity of lcnec there are no large randomized trials that define the optimal treatment approach for either localized or advanced disease 1.

The author herein reports a large cell neuroendocrine carcinoma lcnec of the lung diagnosed in an axillary lymph node without clinical data with an emphasis of kit and pdgfra. Large cell neuroendocrine carcinoma lcnec has emerged as a separate entity among pulmonary endocrine neoplasms and the criteria for its histologic diagnosis are now well described. However cytologic diagnosis presents more difficulties and to the authors knowledge few cytologic studies concerning the entity have been published to date.

An excisional biopsy of an axillary lymph.