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Ros season 15. A comparative study of epithelioid mesothelioma and lung adenocarcinoma. The immunohistochemical diagnosis of mesothelioma. The histological diagnosis of malignant mesothelioma of the pleura especially the distinction from peripheral adenocarcinoma of the lung may be difficult.
Immunohistochemistry plays an indispensable role in accurate diagnosis of malignant mesothelioma particularly in morphologically challenging cases and in biopsy and cytology specimens where. The immunohistochemical diagnosis of mesothelioma a comparative study of epithelioid mesothelioma and lung. Its histologic diagnosis is stepwise and should be based on morphological assessment associated with clinical and radiological findings and supported by immunohistochemistry as well as more recent molecular tests.
And wt1 are the best positive markers for differentiating epithelioid malignant mesothelioma from pulmonary adenocarcinoma. The best discriminators among the antibodies considered to be negative markers for mesothelioma are cea. The immunohistochemical reports previously published on this subject show diverging results mainly because a variety of antibodies and staining techniques have been used by the different.
The diagnosis of mesothelioma is one of the most difficult challenges faced by pathologists. Immunohistochemical tumor markers are proteins that help doctors tell the difference between different types of cancer. Several new immunohistochemical markers that can assist in the diagnosis of mesotheliomas have been recognized recently.
The diagnosis of malignant mesothelioma may also be difficult because of procedures in sampling fixation and processing and uses of immunohistochemical probes. Author nelson g ordonez 1 affiliation 1 university of texas texas 77030. Checking for direct pdf access through ovid.
This article reviews the current information available on these markers and also provides a practical approach to the immunohistochemical diagnosis of epithelioid mesotheliomas. The immunohistochemical diagnosis of mesothelioma.
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