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Dream a phase 2 trial of durvalumab with first line chemotherapy in mesothelioma with a safety run in topic.

People with mesothelioma. We had ten sites open and we recruited 54 patients in 10 months which was 8 months ahead of schedule. Patients with malignant pleural mesothelioma mpm that cannot be surgically removed will receive first line treatment with standard chemotherapy of pemetrexed and cisplatin. Dream was a phase ii trial of durvalumab and chemotherapy in malignant pleural mesothelioma.

Study design and participants. Weve recently seen that combining chemotherapy and immunotherapy can help people with lung cancer live longer said the principal investigator of the study anna nowak md phd of the. These were untreated patients so first line and the study was a phase ii multi centre study in australia.

Dream was a multicentre single arm open label phase 2 trial done in nine hospitals in australia. Eligible patients were aged 18 years or older and had histologically confirmed malignant pleural mesothelioma considered unsuitable for cancer directed surgery an eastern cooperative oncology group performance status of 0 or 1 and measurable disease as per the modified response. Nowak peey sei kok ann livingstone willem joost lesterhuis sonia yip mark donoghoe wei sen lam martin r.

Anz clinical trial registry number. Eligible patients were aged 18 years or older and had histologically confirmed malignant pleural mesothelioma considered unsuitable for cancer directed surgery an eastern cooperative oncology group performance status of 0 or 1 and measurable disease as per the modified response evaluation. Dream was a multicentre single arm open label phase 2 trial done in nine hospitals in australia.

Dream was a multicentre single arm open label phase 2 trial with a safety run in done in nine hospitals in. Eligible patients were aged 18 years or older and had histologically confirmed malignant pleural mesothelioma considered unsuitable for cancer directed surgery an eastern cooperative oncology group performance status of 0 or 1 and. In october the journal of thoracic oncology published the results of the dream study which was testing the efficacy safety and tolerability of durvalumab combined with the standard chemotherapy treatment for patients diagnosed with pleural mesothelioma.

Activity of the combination of cisplatin pemetrexed and durvalumab in patients with no previous systemic therapy for malignant pleural mesothelioma. Pemetrexed combined with cisplatin is currently the preferred first line treatment recommended by oncologists to treat mesothelioma but. The aim of the dream trial was to evaluate the.

Dream was a multicentre single arm open label phase 2 trial done in nine hospitals in australia.

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