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The role of cytologic evaluation of pleural fluid in the diagnosis of malignant mesothelioma. Characterization by ultrastructural and immunophenotypic analysis. Malignant pleural mesothelioma mpm is an aggressive and heterogeneous tumor mainly associated with asbestos exposure.
Nevertheless mesothelioma is the most common malignant disease which occurs on the pericardium so it poses less difficulty to medical professionals. Orengo am spoletini l procopio a et al. Most tumors arise from the pleura and so this article will focus on pleural mesothelioma.
This neoplasm displays a wide variety of histologic patterns and the major dilemmas consist in differential diagnosis with benign mesothelial proliferations and other mimicking malignant tumors. A diagnosis of mesothelioma can be devastating not only to you but also to your family and friends. Pericardial mesothelioma may be mistaken in the absence of a differential diagnosis for pericardial effusion pericardial thickening heart disease heart failure or discreet pericardial mass.
Mesothelioma also known as malignant mesothelioma is an aggressive malignant tumor of the mesothelium. The histological findings of mesothelioma could facilitate its diagnosis and provide important prognostic information. But this can be very challenging using light microscopy alone.
Epithelioid sarcomatoid and biphasic. Sarcomatoid malignant mesothelioma differential diagnosis. Pleural mesothelioma 90 covered in this article.
Renshaw aa dean br antman kh et al. Establishment of four new mesothelioma cell lines. Given the presence of the mesothelium in different parts of the body mesothelioma can arise in various locations 17.
3 to date therapeutic options for mpm are limited with an overall survival ranging from 12 to 18 months and patients affected with sarcomatoid mpm have the worst clinical outcome. Other malignant conditions sarcomas lung cancers metastatic cancers can look similar both clinically and radiographically to mesothelioma and may even look similar under the microscope. Ihc patterns of staining can help distinguish between other types of cancer and mesothelioma.
Establishment of four new mesothelioma cell lines. Characterization by ultrastructural and immunophenotypic analysis. Ask your health care team for information to help you better understand your disease.
Differential diagnosis of sarcomatoid mesothelioma from sarcomatoid tumors involving the pleura peritoneum pericardium and tunica vaginalis is of critical importance for optimal clinical management. 1 2 there are three main mpm histotypes.
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