Ctgf Mesothelioma, Iron Addiction With Ferroptosis Resistance In Asbestos Induced Mesothelial Carcinogenesis Toward The Era Of Mesothelioma Prevention Sciencedirect
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Fig S2 Ctgf Is Present In Kpc Tumors And Plasma A Representative Download Scientific Diagram Https Mesotheliomanet Well Differentiated Papillary Mesothelioma
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High ctgf expression also played a role in the epithelial mesenchymal transition in mm.
Https mesotheliomanet well differentiated papillary mesothelioma. These data suggest that ctgf is an important modulator of mm growth and pathology and represents a novel therapeutic target for this disease. Furthermore ctgf is a novel serum biomarker for both early diagnosis and determining the mm prognosis in rats. The extent of fibrosis and ctgf expression in mesothelioma cells did not correlate with patient prognosis.
If a marker correlates with poor prognosis and tumor stage it is possible that the correlation is driven by tumor stage. We previously reported that overexpression of connective tissue growth factor ctgfccn2 promotes mesothelioma growth thus suggesting it as a novel molecular target. In addition ctgf expression did not correlate with tumor stage.
The data suggest that ctgf cafs are involved in mesothelioma progression and represent a potential molecular target for mesothelioma therapy. Malignant mesothelioma mm is a neoplasm that arises from serosal surfaces of the pleural peritoneal and pericardial cavities with worldwide incidence much of which is caused by asbestos exposure. We further suggest that ctgf may influence the malignancy of mesothelioma because of the different histological expression patterns observed in human mm tissues.
The ctgf score for mesothelioma cells did not correlate with the ki 67 index but that for cafs did. The formation of a yap tead4smad3 p300 complex on the specific ctgf promoter site with an adjacent tead and smad binding motif is a. In mesothelioma ctgf is evident only in the sarcomatoid subtype which is the most aggressive and has the poorest outcome46 in multiple myeloma a cleaved ctgf fragment is increased in plasma and associated with bone disease58 in chondrosarcoma and pan creatic cancer ctgf is transiently increased compared to nor.
In other words the marker is highly expressed in advanced.
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