Vinorelbine Mesothelioma, Mesothelioma Study Shows Mathematical Modeling May Help Determine Best Treatment Schedules

Vinorelbine can relieve symptoms and improve quality of life for mesothelioma patients who cannot tolerate other cancer therapies.

Puzzle colouring pages. Studies suggest that vinorelbine requires a gene called brca1 shown to be absent in 38 of mesothelioma cases in order to induce cell death in mesothelioma. Vinorelbine regimens are not as effective at extending survival as the standard pemetrexed and cisplatin treatment for mesothelioma. Vinorelbine has been used for patients with mesothelioma as part of a first line chemotherapy treatment combination with a platinum based chemotherapy drug like cisplatin but it hasnt proven to be more effective than the current standard of care of pemetrexed and cisplatin.

Mesothelioma is a cancerous condition caused by long term exposure to and inhalation of asbestos fibers. The median number of vinorelbine injections was 12 range 2 to 30. Vinorelbine is a relatively new chemotherapy drug on the mesothelioma scene.

Studies have been conducted that show a degree of effectiveness in reducing the number of cancerous cells present in the pleural lining of the lungs. Vinorelbine shows promise in the palliation of patients with malignant pleural mesothelioma. Malignant pleural mesothelioma mpm is a rapidly progressive invariably lethal tumor.

This drug has shown acceptable response rates in clinical studies and is also being researched for a role in second line treatment for pleural mesothelioma patients who have already had their first round of chemotherapy. Navelbine vinorelbine is a semi synthetic compound thought to slow tumor growth by preventing cancer cells from dividing. French pharmacist pierre potier and his team invented the.

Food and drug administration fda for treating certain cases of non small cell lung cancer and in europe for mesothelioma and other cancers. Additionally some studies have suggested that although it is capable of generating a high rate of stable disease in patients who were previously treated with other chemotherapy drugs there isnt a clear change to. Quality of life analyses showed a benefit for vinorelbine therapy.

Commonly used as a chemotherapy treatment vinorelbine is meant for aggressive cancers like metastatic breast cancer non small cell lung cancer and mesothelioma. Navelbine is approved by the us. However because vinorelbine has shown some effectiveness and has relatively low toxicity doctors have continued to explore its value as a palliative or second line therapy.

The medication comes from the alkaloids extracted from the rosy periwinkle plant scientifically known as catharanthus roseus. The vim trial aims to establish whether vinorelbine in patients with mpm helps them live longer and whether the brca1 gene is helpful in selecting patients most likely to benefit from treatment. The relatively low toxicity of the drug suggests that trials of vinorelbine in combination with other agents should be feasible.

Recently vinorelbine has been used in the treatment of mesothelioma.