Surgery For Biphasic Mesothelioma, Malignant Pleural Mesothelioma Department Of Cardiothoracic Surgery Stanford Medicine

The best strategy of care for biphasic malignant pleural mesothelioma biph mpm is controversial.

Nfl jacoby brissett. Mesothelioma surgery is one of the most effective treatments for this type of cancer. This includes people with sarcomatoid or biphasic mesothelioma very old patients those who have cancer in their lymph nodes and people with elevated crp or platelets. The life expectancy for the different cell types of mesothelioma varies.

Those diagnosed with stage 2 pleural mesothelioma have a life expectancy of 19 months. Biphasic is the second most common cell type for mesothelioma. For the 3 histologic subtypes of malignant pleural mesothelioma mpm epithelioid sarcomatoid and biphasic the magnitude of benefit with surgical management remains underdefined.

Research shows many patients are not good candidates. Mixed or biphasic mesothelioma is made up of tumors that contain both epithelioid and sarcomatoid regions. About 20 to 35 percent of all malignant mesothelioma cases are biphasic.

Treatment for biphasic mesothelioma depends on which cell type makes up the majority of cells in the tumors. Extrapleural pneumonectomy and pleurectomy decortication surgeries are used to treat pleural mesothelioma while cytoreductive surgery is often used for peritoneal mesothelioma. Biphasic cell mesothelioma is found more often in the pleural form of the disease than in other forms of mesothelioma.

Video assisted thoracoscopic surgery vats is increasingly becoming a more common type of surgery for patients with mesothelioma. Patients in each histologic group were dichotomized into those receiving. If the cancer is mostly epithelioid cells then doctors may use surgery since theyll be able to remove them easily.

Tumors that contain more epithelioid cells have a better prognosis than those that contain more sarcomatoid cells. Woodard and jablons say evidence against surgery for mesothelioma is growing. The national cancer data base was queried for newly diagnosed nonmetastatic mpm with known histology.

One of the most successful treatments for peritoneal mesothelioma is combination cytoreductive surgery with intraoperative heated chemotherapy hipec which has led to a five year. Surgery like an extrapleural pneumonectomy may be a viable option for biphasic mesothelioma patients with predominantly epithelial cells and an earlier diagnosis. It is less common than the epithelial cell type and more common than sarcomatoid type.

If the biphasic mesothelioma is made up mostly of sarcomatoid cells then palliative treatments are offered. If one can completely remove the mesothelioma by surgery the prognosis is more favorable than if one cannot remove it.