Spindle Cell Sarcomatoid Mesothelioma, Http Ologyjournals Com Prmij Prmij 00009 Pdf

It accounts for approximately 10 20 of all mesothelioma diagnoses.

Clairton mesothelioma lawyers. Sarcomatoid mesothelioma is a rare cell type caused by asbestos exposure. This is where the nickname spindled mesothelioma comes from. Immunohistochemistry has a more limited role in the diagnosis and distinction of sarcomatoid mesothelioma from other spindle cell neoplasms.

Desmoplastic sarcomatoid cells account for about 5 percent of all mesothelioma diagnoses. Sarcomatoid malignant mesothelioma is a rare tumor that arises in the pleura and can be confused with numerous tumors arising in or metastasizing to the pleura including synovial sarcoma metastatic sarcomatoid carcinoma metastatic melanoma thymoma renal cell carcinoma localized fibrous tumor leiomyosarcoma and other types of sarcoma. What is spindle cell mesothelioma.

Sarcomatoid mesothelioma is often resistant to treatment and has a poor prognosis because its often diagnosed in later stages. Sarcomatoid mesothelioma accounts for 10 20 of all cases and is the most aggressive but least common mesothelioma cell type. Download high res image 661kb download.

Spindle cell mesothelioma refers to a type of disease called sarcomatoid mesothelioma. They appear similar to other types of cancer and the. Spindle cells arranged in fascicles or having a haphazard distribution.

Pleura mesothelioma sarcomatoid. D spindle cells of a sarcomatoid mesothelioma of the pleura showing membrane immunoreactivity for d2 40. Conventional spindle cell type.

This mesothelial marker is the most useful to establish this diagnosis and is positive in approximately 74 of cases pap original magnification 100. The combination of a broad spectrum cytokeratin with calretinin combines both high sensitivity 77 for ae1ae3 with high specificity 100 for calretinin for sarcomatoid mesothelioma and. Sometimes referred to as spindle cell mesothelioma sarcomatoid cells are recognized by their oval spindle shape.

Under a microscope the cells of sarcomatoid mesothelioma are long and spindle shaped. Sarcomatoid mesothelioma is the least common cell type of mesothelioma 10 15 and known for its abnormal spindle shape. Localized sarcomatoid mesotheliomas can only be diagnosed in the presence of spindle cell malignancies that exhibit immunoreactivity for cytokeratin and mesothelial markers and negative immunoreactivity for epithelial lesions in patients that show no multifocal or diffuse pleural spread and no evidence for extrapleural lesions.

Sarcomatoid cells appear in 15 of mesothelioma cases making it the least common mesothelioma cell typethese cells are most commonly found in pleural mesothelioma cases but can also appear in all other forms of mesothelioma. Desmoplastic sarcomatoid cells are long and tend to look like bundles of collagen a healthy protein found in the bones muscle tendons and skin.