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A Novel Targeting Therapy Of Malignant Mesothelioma Using Anti Podoplanin Antibody The Journal Of Immunology Epithelial Mesothelioma
Epithelial mesothelioma. Conversely it is typically but not always absent in carcinomas of the lung and breast. 292296297 padgett et al. Malignant effusion malignant pleural mesothelioma arises from the serosal surfaces of body cavities and is linked to asbestos expo sure.
Cells article targeted phototherapy for malignant pleural mesothelioma. Through tissue staining pathologists use podoplanin to tell the difference between epithelioid mesothelioma and adenocarcinoma a type of cancer that forms in the mucus secreting membranes throughout the body. Podoplanin pdpn is an established diagnostic marker for mpm but the function of pdpn in mpm is not fully understood.
Podoplanin has become a useful immunohistochemical marker for identifying mesothelioma. Near infrared photoimmunotherapy targeting podoplanin yuko nishinaga 1y kazuhide sato 123y hirotoshi yasui 1 shunichi taki 1 kazuomi takahashi 1 misae shimizu 12 rena endo 12 chiaki koike 12 noriko kuramoto 2 shota nakamura 4 takayuki fukui 4 hiroshi yukawa 256 yoshinobu baba 56. However the physiological function of podoplanin in mesothelioma cells is not known.
1the university of texas md anderson cancer center houston tx 77030 usa. Podoplanin aggrus which is a type i transmembrane sialomucin like glycoprotein is highly expressed in malignant pleural mesothelioma mpm. Malignant pleural mesothelioma mpm is characterized by dissemination and aggressive growth in the thoracic cavity.
We previously reported the generation of a rat anti human podoplanin ab nz 1 which inhibited podoplanin induced platelet aggregation and hematogenous metastasis. It was noted that podoplanin is expressed in reactive mesothelial cells. 298 reported that podoplanin was a better marker for smm than calretinin but 30 of.
Podoplanin is a specific marker for lymph vessel endothelial cells. It is relatively rare in frequency but with poor clini cal outcomes mainly because of lack of effective treat ment at present12 therefore accurate diagnosis of malig. D2 40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma.
Podoplanin Enhances Lung Cancer Cell Growth In Vivo By Inducing Platelet Aggregation Scientific Reports Epithelial Mesothelioma
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