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In this issue of thorax creaney et al15 report that soluble mesothelin is detectable in pleural and peritoneal effusions and its levels are significantly higher median 7 fold in pleural mesothelioma n52 than in effusions of benign pleuritis n84 and.

I doug and i have mesothelioma. However not all patients are able to undergo invasive procedures to obtain a biopsy and even when. 15 this would be consistent with the belief that mesothelin is released from pleural mesothelioma cells into the pleural effusion and probably absorbed subsequently into the systemic. The diagnosis of mm is often difficult and may take several weeks to months to establish current guidelines recommend that a diagnosis be based on demonstration of invasion by tumor cells.

In a murine flank model of mesothelioma tumour infused with daily instillations of pleural fluid grew significantly faster over saline controls median 525 cm2 vs 280 cm2 at day 13 p 0028. Sessed bythe studentt test for unpaired values. Mesothelin in pleural fluid as a diagnostic test for mesothelioma.

Pleural fluid levels of soluble mesothelin were significantly higher thanbut strongly correlated tocorresponding serum levels in the study by creaney et al.

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