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Report asbestos removal. Keytruda did not improve progression free survival for mesothelioma patients who progressed after first line chemotherapy. While pembrolizumab was not superior to chemotherapy survival times were similar suggesting. Pembrolizumab does not outperform chemotherapy in mesothelioma.
Pembrolizumab appears to elicit significant clinical activity with durable responses and a manageable safety and toxicity profile in patients with pd l1 positive malignant pleural mesothelioma. There was no treatment related mortality and no discontinuations were attributable to treatment related adverse events. We assessed the safety and efficacy of pembrolizumab an anti programmed cell death receptor 1 pd 1 antibody in advanced solid tumours expressing programmed cell death ligand 1 pd l1 and report here on the interim.
Results from a phase iii clinical trial comparing keytruda pembrolizumab to standard chemotherapy shows the immunotherapy drug still has a long way to go as a viable treatment option for malignant pleural mesothelioma. We investigated outcomes in association with clinicopathological features and expression of programmed death ligand 1 pd l1. Keytruda also known as pembrolizumab is a type of immunotherapy drug that has shown promise in extending the life expectancy of mesothelioma patients.
Nevertheless whilst pembrolizumab was not superior to chemotherapy survival was similar and so pembrolizumab may represent an alternative popat explained that new checkpoint inhibitor studies are needed in patients with earlier stages of mesothelioma than those in promise meso. Approval for treating this kind of cancer came after clinical trial results showed it to be safe and effective. Pembrolizumab is promising for mesothelioma patients.
The therapy is currently in clinical trials to test its efficacy as a mesothelioma cancer treatment. On the basis of promising early results pembrolizumab was used off label in switzerland and australia. There is no approved second line treatment for malignant pleural mesothelioma mpm.
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