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Top 10 law firm in the world. B pax8 immunoreactivity in a biphasic peritoneal mesothelioma. C strong nuclear pax8 immunoreactivity is shown in a well differentiated papillary mesothelioma 33 diaminobenzidine original magnification 100 a through c. Staining was noted in 20 wdpms 61 with 17 showing strong and diffuse nuclear staining and 3 patchyfocal staining.
Differentiate renal collecting duct carcinoma pax8 p63 from urothelial carcinoma of upper urinary tract pax8 p63 am j surg pathol 201034965 differentiate thyroid anaplastic carcinoma pax8 from head and neck squamous cell carcinoma pax8 hum pathol 2011421873. In comparison pax8 staining was only present in 12 650 of epithelioid malignant mesothelioma selected as control cases. The presence of weak staining for pax8 in the 3 noninvasive mesotheliomas questions the use for pax8 in this differential diagnosis.
Follow up information available in 46 cases revealed no signs of tumor progression or local recurrence except for the case that showed transformation to a fully malignant mesothelioma after a period of 15 years. The present cases demonstrated that pax8 negativity may be a useful diagnostic biomarker for differentiating mpm from oc. On the basis of this study h caldesmon is not a useful marker for mesothelioma.
On the other hand the current data on pax8 staining pattern in non epithelial neoplasms is scarce. It should be added that only focal andor weak staining for pax8 was described in pleural malignant mesothelioma 22. Introduction malignant peritoneal mesothelioma mpm is a rare disease that typically demonstrates a poor prognosis with an average survival time of 6 12 months 1.
One study reported pax8 being negative in uterine adenomatoid tumors 14cases of peritoneal mesothelioma. Methylation demethylation and acetylation of histone proteins have implications in cancerogenesis. Pax8 immunostaining and which were consistent with mpm.
In contrast 4 peritoneal mm 12 were pax 8 positive 3 diffuse and 1 focal staining. A an epithelioid malignant mesothelioma with strong pax8 staining. Results of immunohistochemical staining patterns for pax8 are summarized in table 1.
Appropriate positive an ovarian cancer known to be positive for pax8 and a mesothelioma known to be positive for calretinin and negative incubation with secondary antibody only controls were stained in parallel for each round of ihc. Sciforschen o pen hu for scientif ic re se a r ch open access.
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