Nintedanib Mesothelioma Trial, Boehringer Ingelheim Release Clinically Meaningful Data For Oral Nintedanib In Mesothelioma Presented At World Conference On Lung Cancer Biospace

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The angiokinase inhibitor nintedanib has shown promising activity in the lume meso phase ii mpm trial and thus is currently being evaluated in the confirmatory lume meso phase iii trial. Nintedanib as switch maintenance treatment of pleural malignant mesothelioma nemo the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The cancer affects the mesothelium which is a protective membrane surrounding the pleura peritoneum and pericardium.

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This phase ii trial studies how well nintedanib works in treating patients with malignant pleural mesothelioma that has come back.

Mesothelioma treatment standard treatment. Nintedanib is a small molecule enzyme inhibitor being studied as a way to increase the effectiveness of chemotherapy on mesothelioma and certain types of lung cancer. Nintedanib is a type of targeted drug called a cancer growth blocker. Nintedanib in combination with pemetrexed and cisplatin for chemotherapy naive patients with advanced malignant pleural mesothelioma lume meso.

Nintedanib in combination with pemetrexed and cisplatin for chemotherapy naive patients with advanced malignant pleural mesothelioma lume meso. And some have a dummy drug placebo. A double blind randomised placebo controlled phase 3 trial.

Epub 2019 may 15. In clinical trials the drug has shown the ability to prevent mesothelioma cell growth and slow tumor spread metastasis. Nintedanib marketed under the brand names ofev and vargatef is a small molecule enzyme inhibitor.

Nintedanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. A double blind randomised placebo controlled phase 3 trial. Malignant pleural mesothelioma mpm is an aggressive thoracic tumor type with limited treatment options and poor prognosis.

Nintedanib clinical trial shows promise for pleural mesothelioma mesothelioma is a rare incurable and difficult to treat cancer. In this trial some people have nintedanib. The findings highlight the benefit of nintedanib rechallenge and the potential use of continuous antiangiogenic therapy in mpm treatment.

The main aims of the trial are to. Malignant pleural mesothelioma mpm is a rare neoplasm generally caused by asbestos exposurethis case details how a patient treated with nintedanib during the lume meso study was rechallenged with nintedanib. Researchers have reported more promising results from an international multicenter phase ii clinical trial of the drug nintedanib moving it another step closer to standard of care treatment for pleural mesothelioma.

It stops signals that cancer cells use to divide and grow. See if nintedanib delays or stops the mesothelioma coming back after chemotherapy. Listing a study does not mean it has been evaluated by the us.

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Nintedanib Mesothelioma Trial, Boehringer Ingelheim Release Clinically Meaningful Data For Oral Nintedanib In Mesothelioma Presented At World Conference On Lung Cancer Biospace

This phase ii trial studies how well nintedanib works in treating patients with malignant pleural mesothelioma that has come back.

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