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Ijms Free Full Text Nf2 Merlin Inactivation And Potential Therapeutic Targets In Mesothelioma Genetic Testing For Mesothelioma
High Incidence Of Somatic Bap1 Alterations In Sporadic Malignant Mesothelioma Journal Of Thoracic Oncology Genetic Testing For Mesothelioma
Genetic testing for mesothelioma. Although asbestos causes malignant pleural mesothelioma mpm rising from lung mesothelium the molecular mechanism has not been suggested until now. Neurofibromatosis 2 nf2 is caused by inactivating mutations of the nf2 tumor suppressor gene. Mutations of the neurofibromatosis 2 nf2 tumor suppressor gene cause the inherited disorder nf2 and are also common in malignant mesothelioma which is not a characteristic feature of nf2.
The authors report an asbestos exposed person with nf2 and malignant mesothelioma. To determine if the neurofibromatosis type 2 gene nf2 located on chromosome 22 participates in the oncogenesis of these neoplasms we studied dna from lung cancer cell lines and mesothelioma using southern blot analysis and the single strand conformation polymorphism sscp technique for mutations covering 8 of the 16 known exons of nf2. Mutations of the neurofibromatosis 2 nf2 tumor suppressor gene cause the inherited disorder nf2 and are also common in malignant mesothelioma which is not a characteristic feature of nf2.
Immunohistochemical analysis of the mesothelioma confirmed loss of. Somatic nf2 mutations also occur in a high proportion of human primary malignant mesotheliomas. The tumor suppressor merlin is encoded by the neurofibromatosis type 2 gene nf2 which is located on chromosome 22q12 and mutations in this gene have been found in 40 of mesothelioma.
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