Nf2 Immune Response Mesothelioma, Radio Immunotherapy And Chemo Immunotherapy As A Novel Treatment Paradigm In Malignant Pleural Mesothelioma Wu Translational Lung Cancer Research
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For the first time in mesothelioma a group of researchers sequenced the genome of 74 malignant pleural mesothelioma tumors.
Unicorn kitty cat coloring pages. The reported case of long survivor peritoneal mesothelioma by serio et al. Generation and immune response could be explored. Introduction malignant mesotheliomamm is a highly aggressive tumour of serosal surfaces.
According to the authors the study provides a deeper understanding of histology independent 17 determinants of aggressive behavior and defines a novel genomic subtype with tp53 and 18 setdb1 mutations and extensive loss of heterozygosity and discover. Loss of bap1 nf2 and cdkn2ab tumour suppressor gene function is frequently observed in malignant mesothelioma. Did not display any of the mutations in the frequently mutated genes bap1 cdkn2a or nf2 and was treated with oxaliplatin a known inducer of immunogenic cell death.
Nf2 is linked various cell signaling including cell cell junction and hippo pathway. Therefore the restoration of nf2 functions is expected to cure a lar ge population of mesothelioma patients. In this study we also revealed the novel function of nf2 inhibitor of snail.
In mesothelioma cell lines merlin loss activates mtor complex 1 mtorc1 signaling and cells with nf2 mutations are selectively sensitive to drugs targeting mtorc1. These data provide the rationale for studying mtor inhibitors such as everolimus in patients with mesothelioma. Therefore if more tissue were available from mesothelioma patients treated with oxaliplatin it would be interesting to establish a cohort where potential neoantigens generation and immune response could be explored.
Nf2 is one of the most frequently mutated genes in mesothelioma. However its molecular role has not been clearly demonstrated. Recently clinical trials that used immunotherapy strategies have yielded promising results but the benefits are restricted to a limited number of patients.
Malignant mesothelioma mm especially its more frequent form malignant pleural mesothelioma mpm is a devastating thoracic cancer with limited therapeutic options. In fact nf2 is one frequently mutated genes in mpm. Nf2 and cdkn2a are other somatic mutations seen in mesothelioma47 nf2 mutations are present in approximately 50 per cent of mesothelioma cases47 nf2 encodes the protein merlin which is involved in several cellular signaling pathways such as mammalian target for rapamycin mtor focal adhesion kinase and hippo.
To mesothelioma has progressed greatly since the seminal observation of the high frequency of nf2 mutations in mesothelioma 89 understanding of the mechanisms underlying bap1 are less advanced. The vast majority of cases of mesothelioma are linked to asbestos exposure.
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