Modified Recist Criteria Mesothelioma, Pdf Modified Recist Criteria For Assessment Of Response In Malignant Pleural Mesothelioma Anna Nowak Academia Edu

Tumour thickness perpendicular to the chest wall or mediastinum was measured in two positions at three separate levels on thoracic ct scans.

Mesothelioma gross specimen. Modified recist mrecist for mesothelioma developed to address the limitations of recist when applied to the unique morphology and growth pattern of this disease has become the standard response assessment paradigm for mesothelioma clinical trials2 3 4 5 6 mrecist specifically changed only the approach to tumor measurement from longest tumor diameter which is ill defined in mesothelioma to tumor thickness perpendicular to the chest wall or mediastinum and limited the number of. We have developed modified recist criteria that are specifically designed to address the unique growth pattern of pleural malignant mesothelioma. The current de facto standard for the assessment of mesothelioma tumor response modified recist response evaluation criteria in solid tumors was published in 2004 as a research paper.

The modified recist1 system that was published in 2004 enabled more accurate measurements of the pleural rind by implementing six perpendicular chest wall measurements from three separate. We have developed and validated modified recist criteria adapted to the growth pattern of malignant pleural mesothelioma. The application of recist criteria could however be variably interpreted by different investigators in mesothelioma and this may lead to unsatisfactory results.

We have developed modified recist criteria that are specifically designed to address the unique growth pattern of pleural malignant mesothelioma. Modified recist criteria modified recist criteria were developed. Response assessment in mesothelioma using the response evaluation criteria in solid tumors recist continues to be challenging with higher disagreement between investigators that with other solid tumors.

Use of these modified response criteria did not materially alter the response rates in our two previous trials. The current clinical method for tumor response assessment in mesothelioma is the modified response evaluation criteria in solid tumors recist guidelines which calls for two linear measurements of tumor thickness to be summed from each of three axial sections primarily in computed tomography ct scans 6 7. Practical application of the modified recist guidelines has suffered from varied interpretations resulting in inaccuracies and inconsistencies in tumor response assessment across and within mesothelioma clinical trials.

The major problems in applying the recist criteria to malignant pleural mesothelioma are in the interpreta tion of the meaning and placement of the longest unidimensional diameter of the target tumour mass to be measured. The longest diameter of a tumour mass. We evaluated 73 patients from two clinical trials of cisplatingemcitabine chemotherapy in malignant pleural mesothelioma.