Moc31 Mesothelioma, Primary Malignant Pericardial Mesothelioma Jacc Case Reports

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Minimal andor focal cytoplasmic staining for moc31 was noted in 13 of cases of reactive mesothelial cellsmesothelioma. Moc31 is a monoclonal antibody that recently was reported to aid in distinguishing adenocarcinoma from mesothelioma in tissue specimens. This study addresses whether this antibody might be helpful in distinguishing between hcc primary cholangiocarcinoma and metastatic adenocarcinoma in the liver.

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The neoplastic cells were negative for moc31 and berep4 and with that morphology and immunophynotype this case was diagnosed as malignant mesothelioma sarcomatoid type.

Coloring pages for adults hard. In this study we examined the utility of this antibody in pleural effusions. Fish if in doubt a fish can also be performed for cdkn2a. Moc 31 is an antibody that recently was reported to be useful in distinguishing adenocarcinoma from mesothelioma in tissue specimens.

Author n g ordonez 1 affiliation 1 university of texas md. Calretinin is a useful marker in differentiating mesothelioma of the epithelial type from adenocarcinoma in serous effusions. 4 6 in this study we examined the utility of moc31 in distinguishing adenocarcinoma from reactive mesothelial cells in pleural effusion specimens.

Eighty nine archival formalin fixed paraffin embedded cell blocks representing 59 adenocarcinomas 12 other neoplasms. The fried egg appearance or cytoplasmic and nuclear staining pattern is characteristic of cells of mesothelial origin. Value of the moc 31 monoclonal antibody in differentiating epithelial pleural mesothelioma from lung adenocarcinoma hum pathol.

A diagnosis of malignant mesothelioma mm carries grave implications due to an almost universally fatal disease course. Eleven cases of metastatic adenocarcinoma were found to be negative for moc31 4 cases from lung tumors 2 from stomach tumors 2 from colon tumors 2 from breast tumors and 1 from a renal tumor. Despite an increase in incidence in the last several decades mm is still a relatively rare disease and most pathologists do not accrue substantial experience with this entity outside of large academic centers.

After analyzing the results it is concluded that from a practical point of view a combination of two positive mesothelioma markers wt1 and calretinin or mesothelin with two negative mesothelioma markers p63 and moc 31 would allow the differential diagnosis to be established between epithelioid mesotheliomas and squamous carcinomas of the. Recently anti moc31 a monoclonal antibody directed against a cell surface glycoprotein has been shown to be helpful in distinguishing between adenocarcinoma and mesothelioma.

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Moc31 Mesothelioma, Primary Malignant Pericardial Mesothelioma Jacc Case Reports

The neoplastic cells were negative for moc31 and berep4 and with that morphology and immunophynotype this case was diagnosed as malignant mesothelioma sarcomatoid type.

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