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Current Chemotherapy Strategies In Malignant Pleural Mesothelioma De Gooijer Translational Lung Cancer Research Robles Law Firm
Robles law firm. A search of the literature found limited evidence to support the use of carboplatin and pemetrexed for the treatment of mesothelioma. Patients and methods chemotherapy naive patients with measurable disease and adequate organ function who were not eligible for curative surgery received pemetrexed 500 mgm2 and carboplatin area under. The aim of this study was to evaluate the activity and toxicity of pemetrexed and carboplatin combination as first line chemotherapy in malignant pleural mesothelioma mpm.
The expert reference panel supported publication of the protocol on the basis of the information summarised below. Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment. A phase ii study clin lung cancer.
Mesothelioma patients are typically given a combination of carboplatin and alimta also known as pemetrexed through an iv to help slow down the spread of cancer. Patients with malignant pleural mesothelioma a rapidly progressing malignancy with a median survival time of 6 to 9 months have previously responded poorly to chemotherapy. We conducted a phase iii trial to determine whether treatment with pemetrexed and cisplatin results in survival time superior to that achieved with cisplatin alone.
Pemetrexed and carboplatin is a combination treatment used to treat mesothelioma and non small cell lung cancer nsclcit is best to read this information with our general information about chemotherapy and the type of cancer you have. Patients and methods patients with measurable advanced mpm and a zero to two eastern cooperative oncology group ecog performance status ps were enrolled. This multicenter phase ii clinical study was conducted to evaluate the activity of the combination of pemetrexed and carboplatin in patients with malignant pleural mesothelioma mpm.
Eligible patients received pemetrexed 500 mg m 2 carboplatin area under the plasma. The aim of this open label phase ii study nct00407459 was to assess the activity of the vascular endothelial growth factor vegf inhibitor bevacizumab combined with pemetrexed and carboplatin in patients with previously untreated unresectable malignant pleural mesothelioma mpm. Carboplatin plus pemetrexed as first line treatment of patients with malignant pleural mesothelioma.
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