Mesothelioma Natural History, Changing Pattern In Malignant Mesothelioma Survival Sciencedirect
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Diagnotis and managt of malignant mesothelioma lbtient history a comprehensive history for patients suspected of having malignant mesothelioma must focus on a period of 20 to 49 years before and should include the occupations offamily members living with the patient during this interval.
Family lawyer. Even the most comprehensive history may fail to establish asbestos exposure in about 30 of cases. The exposure to the asbestos that cause mesothelioma occurrs 25 40 years to appear. Malignant pleural mesothelioma has a well described natural history but poorly defined pathogenesis.
Chest tube drainage and sclerosis pleurodesis may. Mesothelioma is traditionally thought of as a primary tumour that rarely metastases this case report adds to growingevidenceto support that thisisnotauniversaltruth and the tumour is capable of spreading to a variety of sites. Repeated tapping of the pleural fluid may initially control pleural effusion and these symptoms.
A combination of cisplatin and pemetrexed has shown an increase in median survival 8 we propose that this may effect a change in the natural history of the disease. A comprehensive history for patients suspected of having malignant mesothelioma must focus on a period of 20 to 40 years before and should include the occupations of family members living with the patient during this interval. Malignant mesothelioma is usually an aggressive disease.
This is further supported by findings from thoracic surgical studies where metastatic mesothelioma can become the predominant pattern of failure following aggressive surgical. Reported cases of symptomatic mesothelioma metastases remain rare and most are noted post mortem. Pleural effusion can cause significant symptoms like breathing difficulty and chest wall pain.
The prognosis of mesothelioma depends on the cell subtype. Metastasis outside the thoracic wall occurs late in the course of pleural mesothelioma. A predominantly locally invasive disease the success of more aggressive life prolonging therapies has increased the potential for the development of distant metastases in survivors.
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