Mesothelioma Immunohistochemical Panel, Http Ajcp Oxfordjournals Org Content Ajcpath 112 1 75 Full Pdf

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Malignant Mesothelioma A Histomorphological And Immunohistochemical Study Of 24 Cases From A Tertiary Care Hospital In Southern India Hui M Uppin Sg Bhaskar K Kumar Nn Paramjyothi Gk Indian J Cancer

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Malignant mesothelioma is a rare neoplasm of the serosal membranes. The best discriminators among the antibodies considered to be negative markers for mesothelioma are cea moc 31 ber ep4 bg 8 and b723. There are numerous tests and panels available but no single test is perfect for distinguishing mesothelioma from carcinoma or even benign versus malignant.

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The world health organization provides guidance on the classification of malignant mesothelioma but its diagnosis remains a challenge for many practicing surgical pathologiststo aid accurate diagnosis the international mesothelioma interest group imig periodically publishes pathologic guidelines on the.

Kazan russia map. Malignant mesothelioma mm versus other malignant tumors and malignant versus reactive mesothelial proliferations. Contextthe pathologic approach to pleural based lesions is stepwise and uses morphologic assessment correlated with clinical and imaging data supplemented by immunohistochemistry ihc and more recently molecular tests as an aid for 2 main diagnostic problems. Immunohistochemical tumor markers are proteins that help doctors tell the difference between different types of cancer.

Proteins such as cytokeratin 56 calretinin wt 1 and podoplanin help pathologists differentiate mesothelioma from other cancers such as lung cancer. Since the last decade various immunohistochemical markers that can facilitate the diagnosis of epithelioid mesothelioma have become available. A panel of four markers two positive and two negative selected based upon availability and which ones yield good staining results in a given laboratory is recommended.

Immunohistochemical studies play an important role for the pathologist in differentiating malignant mesothelioma from neoplastic mimics such as breast or lung cancer that has metastasized to the pleura. Adenocarcinoma calretinin cea immunohis tochemistry mesothelioma thrombomodulin wt1 the differential diagnosis between epithelioid. 4 5 to.

Between epithelioid mesothelioma and lung adenocarci noma the combination of cea calretinin and each wt1 or thrombomodulin was suggested to be the best panel of immunohistochemical markers. 4 5 a particular issue is the lack of reliable positive markers for mesothelial cells in formalinfixed paraffinembedded sections although several reports have claimed variable results.

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