Mesothelioma Calretinin Negative, Mesothelioma Positive For Pan Ck Ck 5 6 Calretinin Wt1 Diagnostic Biosystems Immunohistochemistry Primary Antibodies Monoclonal Antibodies Polyclonal Antibodies Fitc Antibodies Automated Staining Instrumentation Mouse And Rabbit

Differentiation of epithelioid mesothelioma positive from adenocarcinoma negative.

Tully rinckey law firm. The study included 199 cases of pleural mesothelioma in australia and germany. 9 429 lacked any immunoreactivity and 12 571 showed weak sparse coarse granular cytoplasmic staining without nuclear or membranous staining. These tumours are more likely to be highgrade ernegative and display a basallike phenotype.

Mesothelin is found in all mesothelioma cells so it is useful for ruling out certain mesothelin negative cancers such as kidney cancer that has spread to the lungs. After analyzing the results it is concluded that calretinin cytokeratin 56 and wt1 are the best positive markers for differentiating epithelioid malignant mesothelioma from pulmonary adenocarcinoma. Calretinins performance was comparable with mesothelin.

Differentiate as part of a panel epithelioid pleural mesothelioma positive from lung adenocarcinoma negative am j surg pathol 2003271031 differentiate as part of a panel epithelioid peritoneal mesothelioma positive from ovarian serous papillary carcinoma usually negative am j surg pathol 2007311139 differentiate reactive mesothelial cells positive from carcinomas negative. The best discriminators among the antibodies considered to be negative markers for mesothelioma are cea moc 31 ber ep4 bg 8 and b723. Mesothelin is a protein found on the surface of mesothelial cells and certain types of cancer cells.

Although the rate of positivity in pulmonary adenocarcinomas is low averaging about 10 it appears to be more common in other primary pulmonary carcinomas including. Here the clinicopathological and immunohistochemical characteristics of calretinin positive lung cancer were examined to reduce confusion with malignant mesothelioma. Eleven per cent 653 of the tumours were classified as basallike.

All adenocarcinoma specimens were classified as negative for calretinin staining. The latter contained predominantly spindle shaped neoplastic mesothelial cells in the cell block preparations. Of these four were positive for calretinin and two were negative p 0003.

It compared calretinin to mesothelin an established biomarker found in all mesothelioma cells. Differentiate as part of a panel epithelioid pleural mesothelioma positive from lung adenocarcinoma negative am j surg pathol 2003271031 differentiate as part of a panel epithelioid peritoneal mesothelioma positive from ovarian serous papillary carcinoma usually negative am j surg pathol 2007311139 differentiate reactive mesothelial cells positive from carcinomas negative. Fifteen per cent of breast carcinomas stain with calretinin.

Overall the combination of positive ema and negative desmin correctly identified 49 of 52 94 cases of mm whereas the combination of negative ema and positive desmin was seen in 55 of 64 86 cases of reactive mh. Calretinin a mesothelioma marker is sometimes expressed in lung cancer which may complicate the differential diagnosis of mesothelioma.