Mesothelioma And Melanoma Gene, Malignant Mesothelioma Time To Translate Trends In Cancer

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Researchers have discovered that individuals carrying a mutation in the bap1 gene are at greater risk of developing mesothelioma and uveal melanoma. The gene was previously identified as a genetic risk factor for developing mesothelioma in several studies. Can genes cause mesothelioma.

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A study published last week in the medical journal scientific reports shows a new link between melanoma and mesothelioma through the bap1 gene.

Shapiro lawyer. Unlocking the connection between genetic risk factors of mesothelioma helps researchers develop prevention techniques and more effective treatment options. And breast ovarian and prostate tumors. Uveal and cutaneous melanoma.

The bap1 gene brca1 associated protein 1 is a tumor suppressor gene involved in dna repair via homologous recombination. Several studies show mutations of bap1 increase the risk of developing mesothelioma. The genetic components of malignant mesothelioma are not well understood.

The studywhich was funded by the national cancer institute nci and conducted by scientists at the university of hawaii cancer center honolulu and fox chase cancer center philadelphiawas published online august 28 2011 in the journal. Although genes do not directly cause malignant mesothelioma genetic factors influence cancer development after carcinogen. The most well known mesothelioma genetic risk factor is bap1 a tumor suppressor gene.

Asbestos is the most important risk factor and cause of this cancer but individual genetics likely also play a role. Likewise melanoma and mesothelioma have previously been linked. Its protein is a ubiquitin carboxy terminal hydrolase a nuclear deubiquitinating enzyme that catalyzes the cleavage of an ubiquitin residue from several proteins.

The discovery that the bap1 gene is involved in a new cancer syndrome characterized especially by uveal melanoma and mesothelioma provides yet another example of the critical importance of the detailed genetic analysis of human tumors said donald blair phd nci. Bap1 syndrome is an autosomal dominant hereditary cancer syndrome associated with increased risk of malignant mesothelioma. Bap1 mim 603089 is located on 3p211 and encodes for a tumor suppressor gene that is frequently mutated in cancer genomes including mesothelioma.

Although melanoma is a much more common form of cancer its listed among.

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Mesothelioma And Melanoma Gene, Malignant Mesothelioma Time To Translate Trends In Cancer

A study published last week in the medical journal scientific reports shows a new link between melanoma and mesothelioma through the bap1 gene.

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