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Intracavitary Cisplatin Fibrin Chemotherapy After Surgery For Malignant Pleural Mesothelioma A Phase I Trial The Journal Of Thoracic And Cardiovascular Surgery Get A Court Appointed Lawyer
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Get a court appointed lawyer. Although cisplatin has been around for a while it is only recently that the drug has been used in conjunction with alimta. More recently cisplatin has been combined with alimta for mesothelioma patients. Chemotherapy helps shrink tumors to extend life expectancy and improve qualify of life by relieving symptoms.
Patients usually receive a combination of chemotherapy drugs most often pemetrexed and cisplatin to target the fast growing cancer cells. Cisplatin is a platinum based anti cancer drug approved by the fda as a cancer treatment since 1978. Cancer is caused by cells that grow abnormally dividing and multiplying at rates that are too fast for the body to control.
Cisplatin cisplatin is a chemotherapy drug that is commonly used to treat cancers such as testicular cancer ovarian cancer bladder cancer and mesothelioma. Malignant pleural mesothelioma mpm is a life threatening cancer of the lungs lining caused by inhaling asbestos fibers that about 20000 americans are diagnosed with each year. Some of the most common side effects experienced by mesothelioma patients receiving cisplatin are nausea vomiting fatigue temporary hair loss and pain around the injection site.
While the fda has approved cisplatin as an anti cancer drug for some time theyve only recently approved it to treat mesothelioma. Mesothelioma chemotherapy is a common treatment strategy for this type of cancer. The drug works by killing the cancer cells through its alkaline properties and is given to the patient through an intravenous line.
Patients with malignant pleural mesothelioma a rapidly progressing malignancy with a median survival time of 6 to 9 months have previously responded poorly to chemotherapy. Other side effects associated with cisplatin include kidney toxicity since the kidneys flush out the chemotherapy as well as low white and red blood cell counts hearing loss and peripheral neuropathy. Cisplatin was first developed to treat testicular bladder and ovarian cancer.
Combined with doxorubicin cisplatin is often used for patients in advanced stages of mesothelioma. We conducted a phase iii trial to determine whether treatment with pemetrexed and cisplatin results in survival time superior to that achieved with cisplatin alone. Used mainly for palliative care this drug combination assists in relieving cancer symptoms and helping patients feel more comfortable.
Cisplatin is also commonly used for heated intraoperative chemotherapy in patients with peritoneal mesothelioma.
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