Mesothelioma Alimta Maintenance, Durvalumab Phase Iii Trial Could Change Mesothelioma Care

Van den bogaert dp1 pouw em van wijhe g vernhout rm surmont vf hoogsteden hc van klaveren rj.

Preschool printable weather coloring pages. Although research is ongoing to find the most effective maintenance treatment alimta is often administered without cisplatin at this point in a patients treatment. Maintenance therapy after all the cycles of alimta and cisplatin are complete maintenance therapy is used to keep mesothelioma cells at bay and prolong remission. Median progression free survival pfs b months 95 ci 15 alimta n359.

21 15 28 only patients with stable disease or better were eligible for continuation maintenance with alimta single agent. 32 27 37 placebo n23. Alimtacisplatin for malignant pleural mesothelioma.

Recent case series have suggested a possible role of re treatment with pbc. Whether pemetrexed maintenance treatment could have led to such an increase in pfs and os remains speculative in the absence of dedicated trial testing such as pemetrexed maintenance in patients with mesothelioma. Maintenance pemetrexed alimta following standard treatment of pemetrexed alimtacisplatin does not prolong progression free survival in patients with pleural mesothelioma.

1department of pulmonary medicine erasmus mc daniel den hoed cancer clinic rotterdam the netherlands. Another explanation for the difference between this study and the 2003 study by vogelzang and colleagues. Pemetrexed maintenance therapy in patients with malignant pleural mesothelioma.

Within the alimta switch maintenance jmen trial design alimtacisplatin was not included as an induction therapy. The role of second line therapy in patients with malignant pleural mesothelioma mpm progressing after first line pemetrexed based chemotherapy pbc is currently undefined. Mesothelioma patients may be able to stay on the drug as part of a maintenance treatment plan if the cancer has remained stable or decreased in size.

Alimta as maintenance therapy may extend survival in mesothelioma patients posted on thursday nov 6 2014 the mesothelioma community closely watches for any study that results in a better quality of life or extended survival for mesothelioma patients. Alimta may extend mesothelioma survival as a maintenance therapy october 23 2014 alex strauss t scientists in japan have just published details of a case they say could be pivotal to the treatment of intractable malignant pleural mesothelioma. All endpoints were measured from the date of randomization which was after completion of 4 cycles of induction chemotherapy.

58 53 63 placebo n78. The process is performed every three weeks for several cycles depending on the patients individual case. In this observational study the activity and saf.

Pemetrexed is given to patients through an iv and takes about 10 minutes to complete.