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The value of extrapleural pneumonectomy epp in the context of multimodality therapy for patients with malignant pleural mesothelioma is controversial.

My little pony printable coloring pages. After the results of the randomized pilot study of the mesothelioma and radical surgery mars trial became available the role of extensive surgery for mesothelioma has recently been questioned. Malignant pleural mesothelioma extrapleural pneumonectomy randomized controlled trial trimodality cancer treatment. Several phase 2 studies have been reported on the role of neoadjuvant chemotherapy epp and postoperative radiotherapy.

Did not focus on surgical trials but did point to fear of being allocated to the placebo arm and a lack of information and support about available trials as barriers to participation. The mars mesothelioma and radical surgery trial is open and recruiting in britain. Malignant pleural mesothelioma is now a common disease particularly in britain but the role of radical surgery had never been examined in a randomised trial.

Patients aged 18 years or older who had pathologically confirmed mesothelioma and were deemed fit enough to undergo trimodal therapy were included. Mars 2 is the worlds only multicentre randomised clinical trial to evaluate the feasibility of recruiting into a trial of surgery for malignant pleural mesothelioma. Findings from the mesothelioma and radical surgery trial 2 mars 2.

2016 has certainly been an exciting year for the trial as we achieved both feasibility endpoints which is the ability to randomise 25 patients in any 6 months or 50 patients. Mesothelioma and radical surgery trial mars disease site. Mesothelioma is a type of cancer that can develop in the covering of the lungs pleural mesotheliomathis trial is for people who have pleural mesothelioma that is only affecting one side of the chest.

Patient experiences of participation in a radical thoracic surgical trial. The mesothelioma and radical surgery trial 2 mars 2 examines the role of radical surgery in the treatment of pleural mesothelioma. Lung cancer other cancers treatment modality.

Extrapleural pneumonectomy is a technically demanding procedure which can only be performed in patients with early stage disease and good performance. The mars trial was rigorously done with the final decision that a patient was eligible for randomisation within mars made in discussions by the mars virtual multidisciplinary team and the allocation to epp or no. To our knowledge mars is the first study to successfully randomly assign patients to epp and no radical surgery for mesothelioma.

These studies have included patients with t13 tumours but differed in the inclusion of n2 status and sarcomatoid. Warnock c lord k taylor b tod a.

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