Lancet Oncology Pembrolizumab Mesothelioma, Drug Resistance In Cancer Immunotherapy New Strategies To Improve Checkpoint Inhibitor Therapies
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Clinical safety and activity of pembrolizumab in patients with malignant pleural mesothelioma keynote 028.
Jurassic world coloring pages. Results of the cohort with malignant pleural mesothelioma from the keynote 028 study suggest that pembrolizumab is a suitable treatment option for patients with malignant pleural mesothelioma with tolerable safety an indication of clinical activity and substantial duration of response. 201035 5 carbone m adusumilli ps alexander hr jr et al. Patients with malignant pleural mesothelioma have poor outcomes with suboptimal therapeutic options and currently no treatment is curative.
Between jan 15 2016 and june 25 2019 1073 patients were enrolled. Ca cancer j clin. Malignant pleural mesothelioma is a rare cancer that is typically associated with exposure to asbestos.
Preliminary results from a non randomised open label phase 1b trial. 1066 participants were treated as of data cutoff june 27 2019 of whom 805 76 were evaluable for tmb and 105 13 of 805 had ttmb high status and were assessed for safety. Preliminary results from the phase 1b non randomised open label keynote 028 trial.
The standard frontline treatment cisplatin plus pemetrexed chemotherapy has only short and insufficient efficacy and no validated treatment beyond. Scientific clues for prevention diagnosis and therapy.
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