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David boies sneakers. Lacourt a et al temporal patterns of occupational asbestos exposure and risk of pleural mesothelioma june 2012 pp. Lacourt a rolland p gramond c astoul p chammings s ducamp s frenay c galateau salle f gilg soit ilg a imbernon e le stang n pairon jc goldberg m iwatsubo y salmi lr brochard p. Lacourt a gramond c rolland p ducamp s audignon s astoul p et al.
Selikoff insulator studies ultimately involved 17800 insulators. Objectives early occupational exposure to asbestos has been shown to be associated with an increased risk of pleural mesothelioma pm which suggests that the timing of exposure might play a role in the doseresponse relationship. These limitations invalidate its results and those of other reports based on the same dataset2 first all cases and controls should be sampled from the same populationtime experience study base3 an alternative.
A higher risk of pleural mesothelioma was observed in subjects non occupationally exposed to asbestos compared to those never exposed. More than 80 of mesothelioma cases in men are attributable to occupational asbestos exposure compared to only 40 in women. Five chance of being true.
56 studies of mesothelioma patients have included. 18 studies involving mesothelioma among insulators and manufacturing employees presented bigger numbers and these studies were not case control research but rather cohort studies. The iwatsubo rodelsperger and lacourt studies involved as few as 125.
The non occupational asbestos arp for these subjects was 200 99 ci 335 to 735 in men and 387 99 ci 84 to 690 in women. Attributable risk in men in two french case control studies on mesothelioma and asbestos. Lacourt a1 rolland p gramond c astoul p chammings s ducamp s frenay c galateau salle f gilg soit ilg a imbernon e le stang n pairon jc goldberg m iwatsubo y salmi lr brochard p.
Lacourt a et al dose time response association between occupational asbestos exposure and pleural mesothelioma may 13 2017 occupational and environmental medicine epub ahead of print. European journal of epidemiology springer verlag 2010 25 11 pp799 806. However none studies has evaluated the relative impact of increasing the annual intensity of occupational exposure to asbestos at each time of the whole exposure.
The study by lacourt reported in a recent issue of occup environ med 1 does not satisfy two fundamental requirements of the design and conduct of a casecontrol study.
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