Is Mesothelioma Genetic, Pdf Pleural Mesothelioma And Lung Cancer The Role Of Asbestos Exposure And Genetic Variants In Selected Iron Metabolism And Inflammation Genes

Secondary exposure or paraoccupational exposure occurs when people are subjected to asbestos fibers or dust but do not directly work with asbestos or asbestos containing products.

Simple unicorn coloring pages. Mesothelioma is not caused by any specific gene. A study published in nature genetics in 2011 describes the cases of two families with a high incidence of mesothelioma. Genetic risk factors for mesothelioma the primary risk factor for mesothelioma cancer is exposure to asbestos fibers.

Genetic biomarkers can be used for early detection of mesothelioma. However recent research into populations of people where mesothelioma is prevalent suggests some individuals may be genetically prone to mesothelioma and other cancers. This disruption of genetic balance leads to cells duplicating living longer than they should and forming clumps known as tumors.

In a recent research carried on white american population in 2012 it was found that people with a germline mutation in their bap1 gene are at higher risk of developing mesothelioma and uveal melanoma. Asbestos causes mesothelioma by piercing into tissue and altering a cells dna. But the disease clusters in families that do not have bap1 mutations suggesting other genes play a role in mesothelioma risk.

Its likely that cancers form because of an interaction between many factors such as inherited conditions your environment your health conditions and your lifestyle choices. Research shows people who inherit a mutated bap1 gene are more vulnerable to developing mesothelioma especially if exposed to asbestos. Very few mesothelioma patients have the genetic variant so testing is not routine.

The bap1 gene when mutated may make the body less able to protect itself from many cancers. Mesothelioma experts know of mutations in only one gene bap1 that are strongly associated with increased risk of mesothelioma. Benefits of mesothelioma genetic testing and research.

One of those cancers is mesothelioma. The key to reducing risk in people with a genetic predisposition for mesothelioma is first knowing they have it. It isnt clear what causes the initial genetic mutations that lead to mesothelioma though researchers have identified factors that may increase the risk.

These mutations also appear to also increase susceptibility to a range of other cancers. Erionite is a zeolite mineral with similar properties to asbestos and is known to cause mesothelioma. There is genetic science behind this cancer and value in continuing to research mesothelioma genetics.

The ohio state researchers recommend genetic testing for family members of people with certain rare cancers. These groups of populations may be geographic groups or groups of relatives.