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Phase 1 study of hsp90 inhibitor ganetespib with pemetrexed and cisplatincarboplatin chemotherapy for pleural mesothelioma.
Dr charmaine myers. Adx 1612 ganetespib is a selective inhibitor of heat shock protein 90 hsp90 a molecular chaperone that controls the folding and activation of client proteins involved in dna repair and cell division. We conducted a dose escalation study to identify the maximum tolerated dose mtd of ganetespib in patients with chemotherapy naive mpm. Listing a study does not mean it has been evaluated by the us.
In this trial researchers want to see if they can improve the treatment of pleural mesothelioma by adding a drug called ganetespib. The response rate was 76 in patients with epithelial histology cancer is located in the epithelial cells the most common type of mesothelioma. The disease control rate responders those with.
The chemotherapy drugs they normally use are pemetrexed and cisplatin or carboplatin. Ganetspib is a targeted therapy drug with potential applications for mesothelioma patients. Doctors can treat mesothelioma with chemotherapy.
More research is needed to evaluate the efficacy of ngr htnf in human subjects and determine whether it should be recommended as a second or third line treatment in mesothelioma patients. Ganetespib with platinum in patients with malignant pleural mesothelioma meso 02 the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Mesothelioma affecting the lungs is called pleural mesothelioma.
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