Epitheliaoid Mesothelioma Ck7 Moderate Wt1 Ki 67, Body Cavityfluids Chapter 3 Differential Diagnosis In Cytopathology

A comparative study of epithelioid mesothelioma and lung adenocarcinoma am j surg pathol 278.

Thanksgiving pictures to color for toddlers. Mild atypia score 2 moderate atypia score 3 severe atypia composite score. 1 0 lee b. 315 in this case the tumor cells were epithelioid and positive for calretinin wt1 ck56 and d240 staining which confirmed the diagnosis of malignant mesothelioma.

The immunohistochemical diagnosis of mesothelioma. 2 3 grade i 4 5 grade ii 6 grade iii. Note cytoplasmic staining as well as positive staining in some nuclei original magnification 400.

Although two malignant pleural mesothelioma markers d2 40 wt1 and two carcinoma markers pcea. Hallmark of epithelioid mesothelioma is the epithelioid cells which are polygonal cells with moderate to abundant eosinophilic cytoplasm vesicular round nuclei and prominent nucleolus. Wt1 estrogen receptor and progesterone receptor as markers for breast or ovarian primary sites in metastatic adenocarcinoma to body fluids.

A epithelioid mesothelioma with fairly typical tubular morphology and relatively uniform nuclei hematoxylin eosin original magnification 400. Epithelioid mesothelioma was the most common histological type 15 cases 625 followed by sarcomatoid 5 cases 2084 deciduoid 2 cases 834 and 1 case each of desmoplastic and biphasic mesothelioma. Malignant mesothelioma is characterized by the presence of positive staining for calretinine ema ck56 wt1 d2 40 mesothelin and the absence of staining for cea ca19 9 ber ep4 moc 31 or ttf 1.

68 to the best of our knowledge this is the first case report of kl 6 producing peritoneal malignant mesothelioma. Nuclear staining in more than 5 of the malignant cells was considered a positive result for the marker. Markers identified as potentially useful in the diagnosis of epithelioid mesothelioma include positive markers namely calretinin keratin 56 d2 40 podoplanin mesothelin and wilms tumor 1.

Staining for pax8 and wt1 was evaluated and scored by 2 pathologists lz. Primary diaphragmatic mesothelioma invading into the liver needs to be differentiated from other tumors of the liver or diaphragm. B positive calretinin in epithelioid mesothelioma.

For positive cases the staining intensity was further graded as weak moderate or strong. D2 40 can be expressed in serous carcinomas. Appropriate negative and positive controls were included.