Diffuse Malignant Mesothelioma Of The Pleura, Malignant Mesothelioma Of The Pleura A Study Of 52 Treated And 64 Untreated Patients Abstract Europe Pmc

Previous asbestos exposure was found in 53 patients 77 with a shorter period of latency for peritoneal mea.

What does chemo do to mesothelioma. In a period of 22 years 37 patients with diffuse malignant mesothelioma of the pleura were seen in a large patient population. Despite many histopathologic similarities between peritoneal and pleural tumors clinical and prognostic features may be quite different. There is a paucity of data evaluating molecular features of peritoneal mesotheliomas.

Diffuse malignant pleural mesothelioma or dmm is a rare but highly aggressive type of cancer. The initial site of involvement was the pleura in 57 patients and the peritoneum in 12. Pleura peritoneum diffuse malignant mesothelioma.

Diffuse malignant mesothelioma of the peritoneum is a rare diagnosis. Strong association with asbestos exposure either occupational eg shipbuilding construction automotive industry or residential industrial contamination environmental domestic br j ind med 196017260 lung cancer 200445s3 incidence varies by geographic location. It occurs in the thin layer of tissue the pleura lining the chest cavity and lungs.

Their ages ranged from 20 to 79 years with an average age of 55 years. Three patients had histories of definite occupational or environmental exposure to asbestos seven had histories of probable exposure and 27 had histories of no known exposure. The annual incidence in the united states is only 3300 cases representing less than 03 of all cancers worldwide although this is likely.

The records of 37 patients with diffuse malignant mesothelioma of the pleura were studied. Diffuse malignant pleural mesothelioma is a rare malignant tumor with an annual incidence in the united states of 2000 to 3000 cases1 its natural history is characterized by local aggressiveness and invasion which left untreated results in a median survival ranging between 4 and 12 months2. Diffuse malignant mesothelioma of the pleura mpm is a highly aggressive tumour that typically is associated with short survival.

Once diagnosed with dmm most patients do not survive beyond one year. From 1974 to 1980 69 patients with ith diffuse malignant mesothelioma were prospectively evaluated. Malignant mesothelioma is an uncommon form of neoplastic transformation of the mesothelial cells that line the serosal surfaces of the body.

Thirty two of the 37 patients were men and five were women. The pathologic final diagnosis was diffuse malignant mesothelioma of the pleura. In clinical differential diagnosis of diffuse malignant mesothelioma of the pleura and pseudomesotheliomatous carcinoma of the lung history of inhalation of asbestos and concentrations of hyaluronic acid in pleural effusion are helpful.

This cancer is more common in men than in women and in older people. Cd70 and cd27 belong to the tumour necrosis factor tnf and the tnf receptor tnfr superfamily respectively. It most commonly affects the pleura and is often associated with pleural effusions and pleural based masses.