Desmin Mesothelioma, Pathology Outlines Desmin

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The diagnostic utility of d2 40 calretinin ck56 desmin and moc 31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology. The use of. Desmin and a sma the results for desmin and a sma are shown in table 4.

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Helps differentiate smooth muscle tumors desmin from gist c kit almost always desmin in serous effusion more common in reactive mesothelial cells 84 than mesothelioma 8 or carcinoma 2 am j surg pathol 2001251405.

Sharma law. 3 scoones dj richman pi. The combination of positive ema and negative desmin strongly favors mm. J pathol 1993169sl188a abstract.

In sarcomatoid mesothelioma positive staining for desmin was observed only in three cases 8 but the reaction was focal 1 or 2 and weak. 1department of pathology beijing chaoyang hospital capital medical university beijing 100020 china. D whitaker d shilkin k.

It consists of a headpiece a tailpiece and an intervening alpha helical midpiece. In pleural and ascitic effusions desmin is easily detected in mesothelium and mesothelioma cells. The latter is highly conserved between species.

Expression of glucose transporter protein 1 and desmin in reactive mesothelial hyperplasia and epithelioid malignant mesothelioma. To our knowledge this case of peritoneal mesothelioma is the first to describe an opposite immunohistochemical profile to that expected being ema negative and desmin positive despite macroscopic and microscopy evidence of malignancy. It has a molecular weight of 53 kd.

Expression of desmin and smooth muscle actin in mesothelial hyperplasia and mesothelioma. Likewise strong membranous positivity for glut 1 andor strong nuclear staining for p53 favors a mesothelioma. However in formalin fixed tissues this marker is often difficult to detect.

Ki67 proliferative index sh. Desmin and neural marker expression in mesothelial cells and mesotheliomas. Distinguishing malignant mesothelioma mm from reactive mesothelial hyperplasia rm may be difficult in effusions.

Article in chinese wei p1 jin ml zhao hy li x diao xl. In addition 60 of sarcomatoid mesotheliomas were positive for a sma and the positive. This study tested the hypothesis that immunocytochemistry ic in effusion cell blocks cb can distinguish mm from rm and that the results may be applied to individual specimens.

Epub 2012 sep 27. Desmin when initially identified in 1977 this intermediate filament was given the designation skeletin. Conversely a combination of negative ema and positive desmin favors a reactive process.

Moreover desmin is generally present mas4 however desmin has never been systematically detected in mesothelial cells and mesotheliomas11 23 we might question whether.

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Desmin Mesothelioma, Pathology Outlines Desmin

Helps differentiate smooth muscle tumors desmin from gist c kit almost always desmin in serous effusion more common in reactive mesothelial cells 84 than mesothelioma 8 or carcinoma 2 am j surg pathol 2001251405.

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