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Easter coloring pages. The only registered systemic treatment for malignant pleural mesothelioma mpm is platinum based chemotherapy combined with pemetrexed with or without bevacizumab. The study is based on pre clinical research that indicates cancer stem cell inhibitors may be effective in treating mesothelioma patients whose tumors are low in the biomarker merlin. The mesothelioma community received a stunning blow last week with the news that verastem is halting its command clinical trialthe company announced sept.
It will be a multi national trial including 11 countries enrolling around 400 patients with pleural mesothelioma. Called the command study the research will look at whether people with malignant pleural mesothelioma could benefit from defactinib a drug which is being developed to target cancer stem cells cells which may cause tumour growth. 28 that it will stop enrollment for futility in the trial of its focal adhesion kinase inhibitor drug vs 6063 or defactinib.
The purpose of the treatment is to prevent tumors from reappearing after the first rounds of chemotherapy with alimta cisplatin and other treatments. The trial alternately called command control of mesothelioma with maintenance defactinib evaluated the use of the new drug defactinib which targets mesothelioma stem cells. Research to discover whether an experimental drug called defactinib could be effective in treating mesothelioma has been launched by the drug company verastem.
The study devised and lead by verastem inc will.
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