Claudin 4 Mesothelioma, M14k And M38k Malignant Pleural Mesothelioma Cell Lines Preserve The Same Claudin Based Phenotype In Vivo
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Claudin 4 Immunohistochemistry Is Highly Effective In Distinguishing Adenocarcinoma From Malignant Mesothelioma In Effusion Cytology Jo 2014 Cancer Cytopathology Wiley Online Library Ticket Clinic Near Me
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Nilai Pax8 Pax2 Napsin A Anhydrase Karbon Ix Dan Claudin 4 Immunostaining Dalam Membezakan Epithelioid Mesothelioma Pleura Dari Sel Karsinoma Sel Metastatik Patologi Moden Patologi Moden 2020 Ticket Clinic Near Me
Claudin 4 is a component of tight junction strands and may play a role in internal organ development and function during pre and postnatal life.
Ticket clinic near me. Claudin4 is a transmembrane protein associated with tight junctions and has been found to be expressed by a large variety of human carcinomas. The purpose of this study is to evaluate the utility of cl 4 immunostaining for assisting in the differential diagnosis of mesothelioma. 12 immunohistochemistry for claudin4 has recently been shown to distinguish adenocarcinoma from malignant mesothelioma with high sensitivity and specificity mostly in surgical specimens.
Claudin 4 in mesothelioma diagnosis. All mesothelioma specimens were negative for claudin 4 but 3 of 18 specimens were focally positive for ber ep4. Claudin 4 immunohistochemistry was performed on cell block paraffin sections and scored for staining intensity staining pattern cytoplasmic versus membranous and percentage of positive tumor cells.
Facchetti f gentili f lonardi s bercich l santin a. The overexpression of claudin 4 has been shown to decrease paracellular electrical conductance due to a selective decrease in na permeability with no significant decrease in cl permeability. Claudin4 is a tightjunctionassociated protein that is expressed in most epithelial cells but is absent in mesothelial cells.
Since claudin4 is not expressed by normal mesothelium we investigated its possible diagnostic usefulness as a negative mesothelioma marker. Claudin 4 immunohistochemistry effectively distinguishes adenocarcinoma from malignant mesothelioma with high sensitivity and specificity in the evaluation of malignant effusions. We compared claudin 4 with ber ep4 and carcinoembryonic antigen as markers to distinguish mesothelioma from lung adenocarcinoma poorly differentiated lung squamous cell carcinoma and serous adenocarcinoma of the uterus or ovary.
13 18 our aim was to. Appropriate positive and negative controls were used throughout. In a large series of malignant effusions this study demonstrated that claudin4 immunohistochemistr.
All cases of mesothelioma were negative for claudin 4 0 of 64. Claudin 4 cl 4 is a tight junctionassociated protein that is expressed in most epithelial cells but absent in mesothelial cells.
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