Ck7 Positive Mesothelioma, Malignant Mesothelioma A Histomorphological And Immunohistochemical Study Of 24 Cases From A Tertiary Care Hospital In Southern India Hui M Uppin Sg Bhaskar K Kumar Nn Paramjyothi Gk Indian J Cancer
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Cytokeratin 56 staining was present in 33 of 34 mesothelioma cases in the study while only six of 67 adenocarcinomas tested positive for the protein.
Dallas cowboy coloring pages. The best discriminators among the antibodies considered to be negative markers for mesothelioma are cea moc 31 ber ep4 bg 8 and b723. The study noted cytokeratin 56 staining may be less useful for peritoneal effusion specimens. Positive and negative mesothelioma tumor markers are used to confirm a diagnosis.
Only about 31 percent of sarcomatoid cases test positive for calrentinin. Sarcomatoid mesothelioma is the rarest cell type and the most difficult to treat. Pathologists may test for podoplanin another immunohistochemical marker when sarcomatoid mesothelioma is suspected.
In patients with mesothelioma hbme1 and calretinin were positive in 100 of patients 7 patients and ttf1 cea and ck7 were negative. An adenocarcinoma with co expression of ck7 er and gata3 is highly specific for breast primary. Effusion or the buildup of excess fluid is a common symptom of pleural and peritoneal mesothelioma.
However rarely urothelial carcinoma choriocarcinoma nephrogenic adenoma and sebaceous. Forty three cases of lung carcinoma 14 squamous cell carcinoma 12 adenocarcinoma 8 small cell carcinoma 3 mesothelioma and 6 metastatic tumors were collected. Other gata 3 positive tumors include choriocarcinoma malignant mesothelioma paraganglioma pheochromocytoma and salivary gland neoplasms.
Proteins such as cytokeratin 56 calretinin wt 1 and podoplanin help pathologists differentiate mesothelioma from other cancers such as lung cancer. Metastatic adenocarcinomas are more likely to express the marker in the abdomen.
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