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Mesothelioma support forums uk. Although following the study of vogelzang et al. Cisplatin is typically combined with another chemotherapy drug like alimta also known as pemetrexed to slow or potentially stop cancer growth in patients with mesothelioma. This antifolate drug interferes with enzymes that are essential for the production and growth of mesothelioma cells.
Pemetrexed and cisplatin is a combination treatment used to treat mesothelioma and non small cell lung cancerit is best to read this information with our general information about chemotherapy and the type of cancer you have. The pivotal vogelzang study compared the efficacy of pemetrexed and cisplatin compared with cisplatin alone and incorporated formal quality of life assessment using the lcss tool gralla et al. Marangolo m vertogen b.
The side effects can include damage to the kidneys nausea and loss of appetite tiredness hair loss and increased risk of infection. Patients with malignant pleural mesothelioma a rapidly progressing malignancy with a median survival time of 6 to 9 months have previously responded poorly to chemotherapy. We conducted a phase iii trial to determine whether treatment with pemetrexed and cisplatin results in survival time superior to that achieved with cisplatin alone.
Alimta pemetrexed most commonly referred to by the brand name alimta pemetrexed is one of the most effective chemotherapy drugs for mesothelioma. Vogelzang nj rusthoven j symanowski j. Mesothelioma of peritoneal origin has wider variation in treatment outcomes than mesothelioma of pleural origin likely because peritoneal mesothelioma comprises borderline malignant variants and aggressive malignant peritoneal mesothelioma mpem.
Phase iii study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. For patients with nsclc consider maintenance pemetrexed after 4 cycles cdf funding required administration pemetrexed is administered first in 100ml sodium chloride 09 over 10 minutes. R statistically superior overall survival time to progression response rate and patient rated quality of life was observed in favour of the.
1 pemetrexed 500 mgm2 iv infusion 1 cisplatin 275mgm iv infusion cycle frequency 21 days number of cycles 4 cycles nsclc or 6 cycles mesothelioma. This study retrospectively evaluates the efficacy of first line systemic pemetrexed and cisplatin chemotherapy in mpem. Cisplatin is a drug that is prescribed to mesothelioma patients which is not very effective alone but coupled with pemetrexedalimta is known to be the chemotherapy agents that provide the most hope.
Bevacizumab For Newly Diagnosed Pleural Mesothelioma In The Mesothelioma Avastin Cisplatin Pemetrexed Study Maps A Randomised Controlled Open Label Phase 3 Trial The Lancet Mesothelioma Support Forums Uk
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