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Clinicopathologic And Genetic Characteristics Of Young Patients With Pleural Diffuse Malignant Mesothelioma Modern Pathology Talc Powder And Mesothelioma
Clinicopathologic And Genetic Characteristics Of Young Patients With Pleural Diffuse Malignant Mesothelioma Modern Pathology Talc Powder And Mesothelioma
Talc powder and mesothelioma. The median age was 14 years range 02 211 years and 55. Peritoneal mesothelioma in the absence of a formal staging system peritoneal mesothelioma is most often characterized by more general mesothelioma stage characteristics as seen above. Patient characteristics as shown in table 2 there was no significant difference in age sex asbestos exposure surgery chemotherapy radiation family history of mesothelioma family history of cancer and personal history of cancer among patients with bap1 mutant and bap1 wild type mpm.
In uveal melanoma and clear cell renal cell carcinoma bap1 mutations are associated with poor outcomes but their clinical significance in mpm is unknown. High mitotic index and non epithelioid histology were the only characteristics associated with a poor overall survival in young patients. The ethnicity percentages changed significantly between the two age groups.
Patients under age 40 also were more likely to have surgery than older ones which could help explain the longer survival. Mesothelioma is an aggressive and hard to treat cancer usually caused by exposure to asbestos. Young patients with pleural mesothelioma have an equal sex distribution and are more likely to have a history of mantle radiation family history of breast cancer and lower rates of cdkn2a deletion than older patients.
Unlike other asbestos related lung diseases it does not appear to be dose dependent 1. In this stage cancer has not yet metastasized to distant sites within the body. 40 80 of patients have a history of asbestos exposure.
The retrospective study evaluated data from 33 patients diagnosed with mesothelioma at age 21 years or younger between 1987 and 2018. Stage 2 pleural mesothelioma is also characterized by the spread of cancer to lymph nodes on the same side of the body as the main tumor. Doctors sometimes rely on the peritoneal cancer index pci which grades tumor size and location by distinct regions in the abdomen.
The clinical characteristics of mesothelioma in the young are distinct from those observed from the older patients including demographic distribution primary site of origin cancer directed surgery rates and outcomes. It can take decades to develop and as a result is usually thought of as a disease of older people. A new report finds that mesothelioma has different characteristics in younger people than it does in the more typical older patients.
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